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[Hypothalamic and pituitary function in brain death].

H Yokota1, S Nakazawa, T Shimura

  • 1Department of Neurosurgery, Nippon Medical School, Tokyo.

Neurologia Medico-Chirurgica
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

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Brain death may not fully eliminate hypothalamic and pituitary function. Some hormone levels remained high, and cellular structures showed signs of life, though clinical significance is unlikely.

Area of Science:

  • Neuroendocrinology
  • Neurology

Background:

  • Investigating hypothalamic and pituitary hormone levels in brain death is crucial for understanding residual endocrine function.
  • The study assessed hormonal status and cellular integrity in patients meeting Japanese criteria for brain death.

Observation:

  • Serum hypothalamic and pituitary hormone levels were inconsistently elevated post-brain death.
  • Cerebral angiography and transcranial Doppler (TCD) assessed cerebral blood flow.
  • Microscopic examination revealed surviving hypothalamic and pituitary cells alongside necrosis.

Findings:

  • Elevated hormone levels persisted, inconsistent with complete cessation of cerebral blood flow.
  • Normal responses to releasing hormones were observed in some patients.
  • TCD detected cerebral blood flow in three patients not identified by angiography.

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Implications:

  • Suggests potential residual viability of hypothalamic and pituitary tissues after brain death.
  • Highlights discrepancies between imaging techniques in assessing cerebral blood flow.
  • Residual function, though present, is likely clinically insignificant in brain death prognosis.