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Updated: Jul 17, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Cognitive functioning in elderly patients with early onset bipolar disorder.

S N T M Schouws¹, J B Zoeteman, H C Comijs

¹GGZ Buitenamstel, Amsterdam, The Netherlands. sigfries@ggzba.nl

International Journal of Geriatric Psychiatry

|January 31, 2007

Summary

Older adults with early-onset bipolar disorder show cognitive impairments in attention, memory, and verbal fluency. These long-term cognitive deficits may be a trait of the illness.

Related Experiment Videos

Last Updated: Jul 17, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Long-term cognitive consequences of bipolar disorder are not well understood.
Bipolar disorder can impact cognitive functions over time.

Purpose of the Study:

To examine neuropsychological functioning in older adults with early-onset bipolar disorder.
Assess cognitive performance in euthymic individuals with a history of bipolar disorder.

Main Methods:

A cohort of 15 older euthymic patients (age >60) with early-onset bipolar I disorder was evaluated.
A comprehensive neuropsychological test battery was administered.
Performance was compared to 15 age, sex, and education-matched controls without mood disorders.

Main Results:

Bipolar disorder patients demonstrated lower scores in selective attention.
Impairments were observed in verbal memory and verbal fluency tasks.
Reduced performance was noted in mental effort tests compared to controls.

Conclusions:

Euthymic individuals with bipolar disorder exhibit cognitive impairments across multiple domains.
These cognitive deficits may represent a trait-like characteristic of bipolar disorder.
Findings suggest potential long-term cognitive disability related to the disease.