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Published on: June 6, 2025
Drug evaluation: PRX-00023, a selective 5-HT1A receptor agonist for depression.
1lntdp@earthlink.net
Current Opinion in Investigational Drugs (London, England : 2000)
|February 1, 2007
Summary
EPIX Pharmaceuticals is developing PRX-00023, a novel 5-HT1A agonist, for depression treatment. A Phase II trial in patients with depression was planned for early 2007.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- EPIX Pharmaceuticals (formerly Predix Pharmaceuticals) is investigating PRX-00023.
- PRX-00023 is an oral aryl piperazine 5-HT1A agonist.
Purpose of the Study:
- To evaluate PRX-00023 as a potential treatment for depression.
- To shift focus from generalized anxiety disorder to depression for PRX-00023 development.
Main Methods:
- The study involves the development of an oral aryl piperazine 5-HT1A agonist.
- A Phase II clinical trial was planned to assess efficacy in depression patients.
Main Results:
- EPIX Pharmaceuticals reported plans to initiate a Phase II trial in November 2006.
- The trial was slated to commence in the first half of 2007.
Conclusions:
- PRX-00023 shows potential for treating depression.
- Further clinical trials are necessary to confirm the efficacy and safety of PRX-00023.
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