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Updated: Jul 17, 2026

Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins
Published on: August 17, 2022
Optimal substrate shape for vesicle adhesion on a curved substrate
Wendong Shi1, Xi-Qiao Feng, Huajian Gao
1Department of Engineering Mechanics, Tsinghua University, Beijing 100084, P. R. China.
Abstract:
When pulling a vesicle adhered on a substrate, both the force-displacement profile and the maximum force at pull-off are sensitively dependent upon the substrate shape. Here we consider the adhesion between a two-dimensional vesicle and a rigid substrate via long-range molecular interactions. For a given contact area, the theoretical pull-off force of the vesicle is obtained by multiplying the theoretical strength of adhesion and the contact area. It is shown that one may design an optimal substrate shape to achieve the theoretical pull-off force.
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