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Updated: Jul 17, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Oxidative stress and antioxidant defence in a healthy nonagenarian population
Emanuela Balbis1, Stefania Patriarca, Anna Lisa Furfaro
1Department of Experimental Medicine, Section of General Pathology, University of Genova, Italy.
Abstract:
Results on oxidative markers during ageing are not consistent throughout the scientific literature; however, successful ageing may depend on better ability to cope with oxidative stress. A previous study of ours showed that successful ageing could actually be related to enhanced response to oxidatively modified proteins. In this study, a healthy nonagenarian population (OVER-90) was examined for various blood oxidative biomarkers and compared with a healthy population of blood donors (age range, 23-66 years). Blood glutathione, both total (tGSH) and oxidised (GSSG), and total plasmatic antioxidant status were maintained in the OVER-90 at a level similar to the control population. Sulphydryl (sulfhydryl) groups and glutathione peroxidase (GPx) were instead decreased. The results are discussed in a possible unifying view: the OVER-90 population could possess a globally preserved antioxidant ability, though some signs of oxidative damage are present and some structures could be 'sacrificed' in order to keep the redox equilibrium.
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