Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aortic aneurysms secrete interleukin-6 into the circulation.

Joe Dawson1, Gillian W Cockerill, Edward Choke

  • 1St. George's Vascular Institute, St. George's Hospital, London, United Kingdom.

Journal of Vascular Surgery
|February 1, 2007
PubMed
Summary

Aneurysms secrete interleukin-6 (IL-6) into the circulation, leading to elevated IL-6 levels within the aorta. This finding correlates with aneurysm size and position, potentially contributing to cardiovascular mortality in patients with aneurysms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chim Chiminee, Chim Chiminee, Chim Chim: For Whom?

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026
Same author

"Ah, but I was so much older then/I`m younger than that now".

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025
Same author

Pilot Study of St George's Vascular Institute Protocol for Comprehensive Assessment of Type B Aortic Dissection Morphology: A Reproducible Protocol for Clinical and Research Applications.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2025
Same author

To Stent or Not to Stent? Is That the Right Question?

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025
Same author

The Delphi Process and Vascular Surgical Practice- Creating Clarity or Contributing to Chaos?

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025
Same author

Relationship between anti-diabetic medication use and glycaemic control: a retrospective diabetes registry-based cohort study in Singapore.

BMJ open·2025

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Vascular Biology

Background:

  • Elevated circulating plasma interleukin-6 (IL-6) is observed in patients with abdominal aortic aneurysms (AAAs).
  • In vitro studies suggest aneurysms are a source of IL-6.
  • IL-6 is an independent risk factor for cardiovascular mortality.

Purpose of the Study:

  • To directly measure in vivo aortic IL-6 concentrations.
  • To test the hypothesis that aneurysms secrete IL-6 into the circulation.

Main Methods:

  • Blood sampling from the aorta in patients with AAA and thoracic aneurysms (TAs) before repair.
  • Control group of patients without aneurysms.
  • Plasma IL-6 measurement via ELISA and high-sensitivity C-reactive protein (hs-CRP) via turbidimetry.

Related Experiment Videos

  • Aneurysm surface area calculation from CT scans.

    • Main Results:

    • Mean IL-6 concentrations were significantly higher in TA and AAA groups compared to controls.
    • Plasma IL-6 concentration correlated with aneurysm position in both AAA and TA groups.
    • A positive correlation was found between aneurysm surface area and mean plasma IL-6.
    • hs-CRP levels were normal, with no significant differences between AAA and control groups.

    Conclusions:

    • Circulating IL-6 is elevated within the aorta of patients with aneurysms and corresponds to aneurysm position.
    • Aneurysm surface area is correlated with mean plasma IL-6 levels.
    • These findings support the hypothesis that aneurysms secrete IL-6, potentially contributing to cardiovascular mortality.