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Updated: Jul 17, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

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Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity

Christopher A Johnston1, David P Siderovski

  • 1Department of Pharmacology and UNC Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7365, USA.

Proceedings of the National Academy of Sciences of the United States of America
|February 1, 2007
PubMed
Summary

This study reveals how peptides from dopamine receptors and G protein subunits work together to activate G proteins. These findings clarify molecular mechanisms of intracellular signaling and receptor-G protein interactions.

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