Related Experiment Video
Updated: Jul 17, 2026

08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Allergy and contact lenses.
Mohammad Siddique1, Bita Manzouri, Tom H Flynn
1Department of Ocular Immunology, Institute of Ophthalmology and Moorfields Eye Hospital, University College London, London, UK.
Chemical Immunology and Allergy
|February 1, 2007
Summary
Allergic conjunctivitis, triggered by allergens and genetics, presents acutely or chronically. This review covers its immune mechanisms and the allergic response to contact lens wear.
Area of Science:
- Ophthalmology
- Allergology
- Immunology
Background:
- Allergic conjunctivitis involves environmental allergens and patient genetic predisposition.
- Classifications include acute (seasonal allergic conjunctivitis) and chronic forms (perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, giant papillary conjunctivitis).
Purpose of the Study:
- To discuss the immune mechanisms underlying various forms of allergic conjunctivitis.
- To explore the specific allergic responses related to contact lens wear.
Main Methods:
- Review of existing literature on allergic conjunctivitis.
- Analysis of immunological pathways involved in ocular allergy.
- Examination of clinical data and mechanisms of contact lens-induced hypersensitivity.
Main Results:
- Detailed explanation of the immune response in seasonal and chronic allergic conjunctivitis.
- Identification of key allergens and inflammatory mediators.
- Understanding of how contact lens materials and wear can trigger or exacerbate allergic reactions.
Conclusions:
- Allergic conjunctivitis is a complex condition with diverse clinical presentations.
- Understanding immune mechanisms is crucial for effective management.
- Contact lens wear presents unique challenges in managing ocular allergies.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions
Overview
Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Cross-reactivity
Overview

