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Normal reference values for hematological parameters, red cell indices, HB A2 and HB F from early childhood through

M A El-Hazmi1, A S Warsy

  • 1Department of Medical Biochemistry, College of Medicine, and King Khalid University Hospital, Riyadh, Saudi Arabia.

Annals of Saudi Medicine
|February 1, 2007
PubMed

Insights

This study establishes normal hematological reference values for Saudi children aged 1-15 years. Findings reveal age-related changes in white blood cells and hemoglobin, providing crucial data for pediatric health in the region.

Area of Science:

  • Pediatric Hematology
  • Clinical Biochemistry
  • Public Health

Background:

  • Hematological parameter values are influenced by age, sex, ethnicity, and environmental factors.
  • Establishing regional reference ranges is essential for accurate diagnosis and monitoring.
  • Normal values for Saudi children in the Central Province were previously undetermined.

Purpose of the Study:

  • To determine reference values for hematological parameters, red cell indices, and hemoglobin types (Hb A2 and Hb F) in healthy Saudi children.
  • To analyze age- and sex-specific variations in these parameters.
  • To compare findings with international reference data.

Main Methods:

  • A cross-sectional study involving 1526 healthy children aged 1-15 years.
  • Hematological parameters, red cell indices, and Hb A2/Hb F levels were measured.
  • Data were analyzed by age groups (15 groups) and sex.

Main Results:

  • White blood cell counts decreased with age from 2 years onward.
  • Hemoglobin and hematocrit levels increased significantly between 2 and 15 years.
  • Saudi children's values showed similarities to Caucasians and intermediate values between Caucasians and African children.

Conclusions:

  • The study provides essential normal reference values for Saudi children and adolescents.
  • These values can aid in the clinical assessment and management of pediatric hematological conditions in Saudi Arabia.
  • Findings highlight the need for region-specific reference ranges.
Abstract

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