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Prevalence of plasma lipid abnormalities in Saudi children
1Medical Biochemistry Department and WHO Collaborating Centre for Hemoglobinopathies, Thalassaemias and Enzymopathies, College of Medicine and KKUH, Riyadh, Saudi Arabia.
Insights
This study assessed lipid levels in Saudi children, finding that 7.72% had borderline high cholesterol and 1.4% had borderline high triglycerides, indicating a need for lipid awareness programs.
Area of Science:
- Pediatric lipidology
- Cardiovascular disease risk factors in children
- Public health and epidemiology
Background:
- Pediatric lipid levels exhibit population-specific variations.
- Elevated lipid levels in children are linked to atherosclerosis development.
- Investigating childhood lipid profiles is crucial for long-term cardiovascular health.
Purpose of the Study:
- To determine the prevalence of dyslipidemia in Saudi children.
- To assess cardiovascular disease risk based on lipid profiles in pediatric populations.
- To inform the development of targeted health interventions.
Main Methods:
- A national household screening program included 2914 children aged 1 to <15 years.
- Fasting blood samples were analyzed for triglyceride and cholesterol levels.
- Prevalence of borderline and high-risk lipid levels was calculated using established guidelines.
Main Results:
- Overall cholesterol ranged from 2.0-5.7 mmol/L; triglyceride levels ranged from 0.1-1.7 mmol/L.
- 7.72% of children were in the borderline risk group and 1.55% in the high-risk group for cholesterol.
- 1.4% were in the borderline risk group and 0.55% in the high-risk group for triglycerides, with variations across age groups.
Conclusions:
- The study highlights the prevalence of dyslipidemia in Saudi children.
- There is a clear need for a lipid awareness program targeting Saudi children.
- Early intervention can mitigate future adult dyslipidemia complications.
Background:
Lipid levels in children vary in different populations. Due to a close association between high lipid levels and development of atherosclerosis, considerable interest has been directed to investigating lipid levels in children.
Materials And Methods:
We conducted this study on 2914 children with ages ranging from 1 year to <15 years, randomly selected during a national household screening program. Fasting blood samples were used for estimation of triglyceride and cholesterol levels.
Results:
The overall range for cholesterol was 2.0-5.7 mmol/L and for triglyceride the overall range was 0.1-1.7 mmol/L. The children were separated into 14 groups depending on age, and the cholesterol and triglyceride levels were calculated in each age group. Using published guidelines for estimating "borderline" and "high risk" for coronary artery disease from cholesterol and triglyceride levels, the prevalence of borderline and high-risk groups was calculated. 7.72% of the children fell in the borderline risk group and 1.55% in the high-risk group using cholesterol values, while using triglyceride values, 1.4% and 0.55% fell in the borderline and high-risk groups, respectively. The prevalence of abnormality varied in the different age groups.
Conclusion:
The paper discusses the need for a lipid awareness program in Saudi children in an attempt to decrease the complications associated with dyslipidemias during adulthood.
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