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Preparation of Artificial Bilayers for Electrophysiology Experiments
09:38

Preparation of Artificial Bilayers for Electrophysiology Experiments

Published on: October 31, 2008

Synthetic ion channels in bilayer membranes

Thomas M Fyles1

  • 1Department of Chemistry, University of Victoria, Victoria BC, CanadaV8W 3P6. tmf@uvic.ca

Chemical Society Reviews
|February 1, 2007
PubMed

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Ion Channels01:19

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Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Voltage-gated Ion Channels

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