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PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis
Young Ho Lee1, Young Hee Rho, Seong Jae Choi
1Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, 136-705, Korea. lyhcgh@korea.ac.kr
Rheumatology International
|February 1, 2007
Summary
Peptidylarginine deiminases 4 (PADI4) gene variations are linked to rheumatoid arthritis (RA) susceptibility, particularly in Asian populations. While some PADI4 polymorphisms increase RA risk in Europeans, the association is stronger in Asians.
Area of Science:
- Genetics
- Immunology
- Rheumatology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex genetic component.
- Peptidylarginine deiminases 4 (PADI4) is a key enzyme involved in citrullination, a process implicated in RA pathogenesis.
- Understanding the role of PADI4 polymorphisms in RA susceptibility is crucial for disease etiology and risk prediction.
Purpose of the Study:
- To conduct a comprehensive meta-analysis of available data on PADI4 polymorphisms and their association with rheumatoid arthritis (RA).
- To investigate whether PADI4 polymorphisms confer susceptibility to RA across different ethnic populations, specifically Asians and Europeans.
Main Methods:
- A meta-analysis was performed using data from eight studies, comprising nine comparisons (three Asian, six European).
- Statistical analysis included assessing the association of PADI4 allele and genotype frequencies with RA risk.
- Odds ratios (OR) and confidence intervals (CI) were calculated to determine the significance of associations and evaluate heterogeneity.
Main Results:
- Overall meta-analysis revealed significant associations between PADI4 polymorphisms (PADI4_94, PADI4_104, PADI4_90) and RA risk (ORs ranging from 1.20 to 1.35).
- All analyzed PADI4 polymorphisms were significantly associated with RA in Asian populations.
- In European populations, only PADI4_94 showed a significant association, while the PADI4 2/2 genotype significantly increased RA risk (OR = 2.10).
Conclusions:
- PADI4 polymorphisms are significant risk factors for rheumatoid arthritis in both Asian and European populations.
- The role of PADI4 gene variations in RA susceptibility appears more pronounced in Asian populations compared to European populations.
- Further research is warranted to explore the contribution of PADI4 gene polymorphisms to RA risk in other ethnic groups.
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