Related Experiment Video
Updated: Jul 17, 2026
10:06
Cell Type-specific Gene Expression Profiling in the Mouse Liver
Published on: September 17, 2019
Expression profiling of liver receptor homologue 1 (LRH-1) in mouse tissues using tissue microarray
Hiroyuki Higashiyama1, Mine Kinoshita, Satoshi Asano
1Pharmacology Department, Tsukuba Research Laboratories, GlaxoSmithKline, 43 Wadai, Tsukuba, Ibaraki, Japan.
Journal of Molecular Histology
|February 1, 2007
Summary
Liver receptor homologue 1 (LRH-1) is crucial for maintaining bodily functions. This study maps LRH-1
Area of Science:
- Endocrinology
- Molecular Biology
- Physiology
Background:
- Liver receptor homologue 1 (LRH-1) is a nuclear receptor.
- LRH-1 is known to be involved in lipid homeostasis and embryogenesis.
Purpose of the Study:
- To elucidate the systemic physiological functions of LRH-1.
- To examine the tissue distribution and localization of LRH-1 in adult mouse tissues.
Main Methods:
- Tissue microarray-based immunohistochemistry was employed.
- Localization of LRH-1 in various adult mouse tissues was analyzed.
Main Results:
- LRH-1 was observed in the nucleus of epithelial cells across the digestive, respiratory, and urinary systems.
- Nuclear LRH-1 was also found in cells regulating metabolism (hepatocytes, adipocytes, cardiomyocytes) and food intake (hypothalamus).
- LRH-1 immunoreactivity was detected in testicular Leydig cells and ovarian follicular cells.
Conclusions:
- LRH-1 plays a significant role in multiple organ systems.
- LRH-1 regulates epithelial cell physiology, differentiation, energy metabolism, and reproduction.
