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Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

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New Chalcones from Bidens pilosa.

B Hoffmann¹, J Hölzl

¹Institut für Pharmazeutische Biologie der Universität Marburg/Lahn, Deutschhausstraße 17 1/2, D-3550 Marburg/Lahn, Federal Republic of Germany.

|February 1, 1988

Summary

Two novel natural compounds, okanin 4'- O-beta- D-(2'',4'',6''-triacetyl)-glucoside and okanin 4'- O-beta- D-(6''- TRANS-P-coumaroyl)-glucoside, were isolated from Bidens pilosa L. Their structures were confirmed using spectroscopic methods.

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Area of Science:

Phytochemistry
Natural Product Chemistry

Background:

Bidens pilosa L. is a plant species known for its diverse phytochemical constituents.
Isolation and characterization of novel compounds contribute to understanding plant chemical diversity.

Purpose of the Study:

To isolate and elucidate the structures of new natural compounds from Bidens pilosa L. leaves.
To provide detailed spectroscopic data for the identified compounds, including okanin 4"- O-beta- D-glucoside (marein).

Main Methods:

Extraction and isolation of compounds from Bidens pilosa L. leaves.
Structure elucidation using UV, FD-MS (Fast-Atom Bombardment Mass Spectrometry), (1)H-NMR (Proton Nuclear Magnetic Resonance), and (13)C-NMR (Carbon-13 Nuclear Magnetic Resonance) spectroscopy.

Main Results:

Isolation of three compounds: okanin 4 - O-beta- D-(2 ,4 ,6 -triacetyl)-glucoside, okanin 4 - O-beta- D-(6 - TRANS-P-coumaroyl)-glucoside, and okanin 3 - O-beta- D-glucoside.
The first two compounds are reported as new natural products.
Comprehensive NMR spectral data for okanin 4 - O-beta- D-glucoside (marein) were obtained and are presented.

Conclusions:

The study successfully identified novel flavonoid glycosides from Bidens pilosa L.
The detailed structural information aids in the chemotaxonomic understanding of the Bidens genus.
This research expands the known phytochemical profile of Bidens pilosa L.