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Related Experiment Video

Updated: Jul 17, 2026

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

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Bufadienolides from Urginea hesperia.

L Krenn¹, M Jambrits, B Kopp

¹Institut für Pharmakognosie der Universität Wien, Währingerstraße 25, A-1090 Wien, Austria.

|June 1, 1988

Summary

This study details the first investigation into the bufadienolide complex of Urginea hesperia, identifying thirteen distinct compounds. These findings expand our knowledge of plant-derived cardiac glycosides.

Area of Science:

Phytochemistry
Natural Product Chemistry
Pharmacognosy

Background:

Bufadienolides are a class of cardiac glycosides with significant pharmacological potential.
Urginea hesperia is a plant species known for its traditional medicinal uses, but its chemical constituents remain largely uncharacterized.

Purpose of the Study:

To conduct the first comprehensive analysis of the bufadienolide complex present in Urginea hesperia.
To isolate and structurally elucidate the individual bufadienolide compounds from the plant extract.

Main Methods:

Extraction of bufadienolides from lyophilized Urginea hesperia plant material.
Isolation of individual compounds using chromatographic techniques.
Structural elucidation using Fast Atom Bombardment Mass Spectrometry (FAB-MS), proton Nuclear Magnetic Resonance ((1)H-NMR), and carbon-13 Nuclear Magnetic Resonance ((13)C-NMR) spectroscopy.

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Main Results:

Successfully isolated thirteen bufadienolides from the Urginea hesperia extract.
Identified and structurally characterized compounds including scillarenin, scilliphaeosidin, and various glycosidic derivatives.
Detailed the specific glycosidic linkages and acetylation patterns for the elucidated bufadienolides.

Conclusions:

This research provides the first detailed compositional analysis of the bufadienolide complex in Urginea hesperia.
The identification of thirteen bufadienolides contributes to the understanding of the phytochemical diversity within the Urginea genus.
The elucidated structures lay the groundwork for future pharmacological investigations into the potential of these compounds.