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Updated: Jul 17, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Moxifloxacin therapy as a risk factor for Clostridium difficile-associated disease during an outbreak: attempts to
Priscilla Biller1, Beth Shank, Leah Lind
1Holy Spirit Hospital, Camp Hill, PA, USA.
Abstract:
An outbreak of Clostridium difficile-associated disease (CDAD) caused by the epidemic North American pulsed-field gel electrophoresis type 1 (NAP1) strain began after a formulary change from levofloxacin to moxifloxacin. Cases of CDAD were associated with moxifloxacin use, but a formulary change back to levofloxacin failed to reduce rates of disease. Substituting use of one fluoroquinolone with use of another without also controlling the overall use of drugs from this class is unlikely to control outbreaks caused by the NAP1 strain of C. difficile.
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