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Updated: Jul 17, 2026

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Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
Published on: June 25, 2015
Efficacy of multiple influenza vaccine delivery systems in a single facility
Anthony A Donato1, Lisa M Motz, Gregory Wilson
1Department of Internal Medicine, Pennsylvania State University Hershey School of Medicine, USA. donatoa@readinghospital.org
Infection Control and Hospital Epidemiology
|February 1, 2007
Abstract:
We retrospectively investigated different inpatient influenza delivery strategies used during 3 consecutive years at a single institution. Vaccination rates were 3% for a physician reminder system, 21% for a manual standing order program, and 43% for a manual standing order program with a provider education program.
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Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

