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Updated: Jul 17, 2026

05:23
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[New guideline for transfusion medicine]
1Transfusion Medicine & Immunohematology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo.
Summary
New guidelines ensure safe blood product transfusion (BPfT) through hospital management systems and clear indication criteria. Autologous transfusion is recommended when feasible, improving patient safety and clinical outcomes.
Area of Science:
- Hematology
- Clinical Pathology
- Health Policy
Context:
- Revised guidelines for Transfusion Practice (TP) and Blood Products for Transfusion (BPfT) align with the 2003 New Blood Law.
- Focus on safe and appropriate TP, including avoiding mismatched transfusions and ensuring sufficient safe blood product supply.
- Addresses domestic demand for blood products.
Purpose:
- To outline essential components of a hospital management system for appropriate TP.
- To detail new criteria for the indication of blood products for transfusion (BPfT).
- To promote safe and effective blood transfusion practices.
Summary:
- Establishes requirements for a practical TP management system, emphasizing active hospital transfusion committee (HTC) involvement.
- Highlights the need for a dedicated transfusion service with laboratory testing, a responsible physician, a manual, and 24-hour support.
- Recommends autologous blood transfusion as the safest option when systems permit.
- Presents detailed criteria for BPfT, including inappropriate use, trigger levels, dosage, and effectiveness evaluation.
Impact:
- Enhances patient safety by minimizing transfusion risks.
- Improves the efficiency and appropriateness of blood product utilization.
- Provides a framework for standardized and effective transfusion services within hospitals.
- Contributes to better clinical outcomes through optimized transfusion management.
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