Related Experiment Video
Updated: Jul 17, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
Efficacy of nitrous oxide inhalation sedation and first permanent molar tooth extractions
1Unit of Dental and Oral Health, Dundee Dental Hospital, Dundee DD1 4HN, UK. jennifer.i.foley@tuht.scot.nhs.uk
Objective:
To determine baseline data in relation to the extraction of first permanent molar teeth during nitrous oxide/oxygen inhalation sedation sessions within the hospital dental service.
Design:
A prospective study.
Setting:
The Department of Paediatric Dentistry, Dundee Dental Hospital, NHS Tayside, UK.
Method:
Data were collected over a 12-month period for patients attending for the extraction of first permanent molar teeth using nitrous oxide/oxygen inhalation sedation.
Results:
Data were available for 133 patients (M: 68; F: 65) with a median age of 11.3 (inter-quartile range 10.0, 12.6) years. Over 80% of cases were treated using a mixture of 30% nitrous oxide and 70% oxygen, with a median sedation time of 30.0 (inter-quartile range 25.0, 40.0) minutes. Overall, 94.0% of cases successfully completed treatment and only 0.75% of cases failed to commence or complete treatment. Regarding each visit, 85.6% and 14.4% of patients underwent single- and multiple-tooth extractions respectively. There were no statistically significant differences between male and female patients, comparing both behaviour (Mann-Whitney U, W = 4,619.9, P = 0.750) and outcome scores (Mann-Whitney U, W = 4,392.5, P = 0.392).
Conclusion:
Extraction of first permanent molar teeth can be successfully achieved using nitrous oxide/oxygen inhalation sedation.
Related Concept Videos
Inhalational Anesthetics: Overview
Stages of General Anesthesia
Parenteral Anesthetics: Overview
Skeletal Muscle Relaxants: Therapeutic Uses
Drug Delivery: Enteral Route
Drugs in...
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...