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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Jul 17, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Work dynamics among persons with systemic lupus erythematosus.

Edward Yelin1, Laura Trupin, Patricia Katz

  • 1University of California, San Francisco, USA. ed.yelin@ucsf.edu

Arthritis and Rheumatism
|February 3, 2007
PubMed
Summary

Employment significantly declines for adults with systemic lupus erythematosus (SLE) over time. Most work loss is due to job cessation, not reduced hours, influenced by demographics and job demands.

Related Experiment Videos

Last Updated: Jul 17, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Area of Science:

  • Rheumatology
  • Occupational Health
  • Health Economics

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease impacting multiple organ systems.
  • Employment and work productivity are significant concerns for individuals with chronic illnesses like SLE.

Purpose of the Study:

  • To assess employment trends in adults (18-64) with SLE from diagnosis to 2004.
  • To estimate changes in annual work hours and identify risk factors for work loss.

Main Methods:

  • A cohort of 982 individuals with SLE was surveyed via telephone.
  • Employment status and work hours were recorded at diagnosis, baseline, and 2004 followup.
  • Kaplan-Meier and Cox regression analyses were used to determine work loss and risk factors.

Main Results:

  • The proportion of employed individuals with SLE decreased from 74% at diagnosis to 54% at followup.
  • Annual work hours declined by 32.2% overall, with total cessation being the primary driver.
  • Demographics and job characteristics significantly predicted work loss.

Conclusions:

  • Total cessation of employment, rather than reduced hours, is the main reason for decreased work hours in SLE patients.
  • Understanding these factors is crucial for developing targeted support for employed individuals with SLE.