Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parental but not child reports of affective lability in offspring predict conversion to bipolar disorder in youth at increased genetic risk.

Journal of affective disorders·2026
Same author

Next-generation precision medicine for pain.

Molecular psychiatry·2025
Same author

Next-generation precision medicine for suicidality prevention.

Translational psychiatry·2024
Same author

Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics.

Molecular psychiatry·2024
Same author

Temporal effects on death by suicide: empirical evidence and possible molecular correlates.

Discover mental health·2023
Same author

Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs.

Molecular psychiatry·2023

Related Experiment Video

Updated: Jul 17, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Towards understanding the schizophrenia code: an expanded convergent functional genomics approach.

H Le-Niculescu1, Y Balaraman, S Patel

  • 1Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|February 3, 2007
PubMed
Summary

Schizophrenia research identifies key genes in GABA neurotransmission, synaptic function, and myelin, suggesting a disorder of brain connectivity. Findings offer new therapeutic targets and highlight molecular overlap with bipolar disorder.

More Related Videos

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Related Experiment Videos

Last Updated: Jul 17, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Classical genetic approaches for schizophrenia have faced significant challenges.
  • Understanding the genetic underpinnings of schizophrenia is crucial for developing effective treatments.

Purpose of the Study:

  • To perform a comprehensive convergent analysis integrating mouse pharmacogenomic data, human genetic linkage data, and human postmortem brain data.
  • To identify candidate genes and pathways involved in the pathophysiology of schizophrenia.
  • To explore potential therapeutic targets and understand the molecular relationship between schizophrenia and bipolar disorder.

Main Methods:

  • Utilized a Bayesian strategy for cross-validation of findings.
  • Integrated gene expression data from a mouse model treated with phencyclidine (PCP) and clozapine.
  • Combined mouse data with human genetic linkage and postmortem brain data.

Main Results:

  • Identified candidate genes primarily involved in GABA neurotransmission (GABRA1, GABBR1, GAD2), glutamate neurotransmission (GRIA2), synaptic function (SYN2, KCNJ4), myelin/glial function (CNP, MAL, MBP, PLP1, MOBP, GFAP), and lipid metabolism (LPL).
  • Highlighted GABA neurotransmission as a prominent factor in schizophrenia pathophysiology.
  • Revealed significant molecular overlap between schizophrenia and bipolar disorder.

Conclusions:

  • Schizophrenia is suggested to be a disorder of brain functional and structural connectivity, with a significant role for GABA neurotransmission.
  • Findings provide potential avenues for pharmacotherapy augmentation and identify novel drug targets.
  • The study underscores the importance of integrating diverse data types for robust gene discovery in complex psychiatric disorders.