Preferred drug lists and Medicaid prescriptions
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Updated: Jul 17, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Tamer Abdelgawad1, Lisa Egbuonu-Davis
1Pfizer Inc, New York, NY 10017, USA. tamer.abdelgawad@pfizer.com
Background:
When Medicaid preferred drug lists (PDLs) are implemented, they may impose indirect costs on prescribing physicians and Medicaid patients, leading to an unintended reduction in the number of Medicaid prescriptions filled.
Objective:
To test retrospectively the proposition that PDLs adversely affect the number of Medicaid prescriptions filled.
Data And Methods:
We compared three 'test' states (Alabama, Texas, and Virginia) that implemented PDLs with restrictions on the prescription of statins with three 'control' states (New Jersey, North Carolina, and Pennsylvania) that did not implement drug access restrictions. We conducted the analysis at the county level and used a differences-in-differences approach that allows for county and time-period fixed effects.
Results:
We found that PDLs adversely impacted several measures of filled Medicaid prescriptions in the 'test' states relative to the 'control' states.
Conclusion:
There are unintended but potentially harmful consequences to cost-focused health policy interventions.
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