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Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
Published on: December 2, 2014
Left ventricle remodelling by double-patch sandwich technique.
Ernesto Tappainer1, Vinicio Fiorani, Nicola Pederzolli
1Cardiac Surgery Unit, Carlo Poma Hospital, Viale Albertoni 1, 46100 Mantua, Italy. tap04@libero.it.
Journal of Cardiothoracic Surgery
|February 3, 2007
Summary
The double-patch sandwich technique effectively reconstructs the left ventricle after aneurysm excision, improving heart function and patient outcomes without increasing risks. This method simplifies surgical repair for postinfarction left ventricular aneurysms.
Area of Science:
- Cardiovascular Surgery
- Cardiac Reconstruction
- Myocardial Repair
Background:
- The sandwich double-patch technique offers an alternative for left ventricle reconstruction after postinfarction dysfunctional myocardium excision.
- Addresses technical challenges posed by thick ventricular wall edges encountered in such procedures.
Purpose of the Study:
- To evaluate the efficacy and safety of the sandwich double-patch technique for left ventricular aneurysm repair.
- To assess the impact of this technique on ventricular volumes, ejection fraction, and patient outcomes.
Main Methods:
- Applied the sandwich double-patch technique to 12 patients with postinfarction antero-apical left ventricular aneurysms over a 5-year period.
- The ventricular opening was secured between two smaller patches, sutured with a single row of stitches, effectively narrowing the cavity and closing the ventricle.
Main Results:
- Significant improvements observed in left ventricular volumes and ejection fraction (p < 0.001).
- All patients experienced symptom-free recovery, with NYHA class improving from 2.5 to 1.2 (p < 0.001).
- Low morbidity with a mean postoperative hospital stay of 10.5 days.
Conclusions:
- The double-patch sandwich technique (bi-patch closure) provides advantages for left ventricular aneurysm excision.
- This method simplifies the repair process by avoiding complex suturing techniques required for linear closure or endoventricular patch repair.
- The technique demonstrates acceptable morbidity and mortality, offering a safe and effective reconstructive option.

