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Related Experiment Videos

Is aging preprogrammed? Observations from the brain/gut axis.

R J Greenstein1, M M Ybanez, R L Zhang

  • 1Department of Surgery, VAMC Bronx 10468.

Mechanisms of Ageing and Development
|December 2, 1991
PubMed
Summary
This summary is machine-generated.

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Aging alters gene expression in the brain-gut axis. Cholecystokinin (CCK) peptide levels change differently in the aging rat brain and intestine, indicating programmed control.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Aging Research

Background:

  • The neuro-enteral axis, connecting the brain and gut, undergoes age-related changes.
  • Gene expression patterns can differ between the brain and intestine during aging.

Purpose of the Study:

  • To investigate age-related differential gene expression in the neuro-enteral axis of Sprague-Dawley rats.
  • To quantify changes in organ weight, RNA, protein, and peptide concentrations with age.

Main Methods:

  • Quantification of brain and gut organ weight, total RNA, and total protein in rats at 4, 10, and 37 weeks of age.
  • Measurement of cholecystokinin (CCK), VIP, and secretin peptide concentrations in brain and duodenum.

Main Results:

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  • Total RNA decreased in the aging brain but remained stable in the gut.
  • Duodenal protein concentration increased with age, while brain protein levels were stable.
  • Smaller CCK forms decreased in the brain but were stable in the gut; larger CCK forms were stable in the brain but increased in the gut.

    • Conclusions:

    • Aging leads to differential changes in RNA and protein concentrations between the brain and intestine.
    • Age-related alterations in CCK peptide forms suggest programmed gene expression control within the neuro-enteral axis.