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Updated: Jul 17, 2026
Cerebellar Regional Dissection for Molecular Analysis
Published on: December 5, 2020
Serial analysis of gene expression profiles of adult and aged mouse cerebellum
Magdalena C Popesco1, Shili Lin, Zailong Wang
1Department of Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Abstract:
Changes in specific cerebellar molecules contribute to impaired balance and motor coordination frequently observed in aged individuals. Serial analysis of gene expression (SAGE) was used to construct six libraries from adult and aged mouse cerebella. Combined unique tags for each group revealed 325 genes that were differentially expressed (p-chance
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