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Flunarizine in migraine attack.

¹Neurology Department, University Hospital, Zurich, Switzerland.

Journal of Cardiovascular Pharmacology

|January 1, 1991

Summary

This summary is machine-generated.

Flunarizine offers a safer alternative for migraine treatment, potentially reducing attack frequency and severity. Further research is needed to confirm its efficacy in preventing rebound attacks.

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Area of Science:

Neurology
Pharmacology

Background:

Conventional migraine treatments pose risks like increased attack frequency, treatment resistance, dependency, and abuse.
Ergotamines present additional vascular risks, necessitating safer alternatives.

Purpose of the Study:

To evaluate flunarizine as a potential alternative migraine therapy.
To investigate the efficacy and tolerability of intravenous flunarizine in suppressing migraine attacks.

Main Methods:

Double-blind, placebo-controlled studies were conducted.
Intravenous administration of 20 mg flunarizine was compared against a placebo.

Main Results:

Intravenous flunarizine (20 mg) demonstrated superiority over placebo in suppressing migraine attacks.

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The treatment was well tolerated by participants.

Conclusions:

Flunarizine shows promise as an effective and well-tolerated option for migraine management.
Further investigation is warranted to explore its potential in reducing rebound attacks.