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Association between multidisciplinary care and survival for elderly patients with chronic kidney disease
Brenda R Hemmelgarn1, Braden J Manns, Jianguo Zhang
1Department of Medicine, Community Health Schiences, University of Calgary, Calgary, Canada. brenda.hemmelgarn@calgaryhealthregion.ca
Insights
Multidisciplinary care (MDC) significantly reduced mortality risk in elderly chronic kidney disease (CKD) patients. While not statistically significant, MDC showed a trend toward lowering hospitalization risks, warranting further investigation.
Area of Science:
- Nephrology
- Geriatrics
- Health Services Research
Background:
- The impact of multidisciplinary care (MDC) on health outcomes for chronic kidney disease (CKD) patients remains unclear.
- Elderly CKD patients represent a vulnerable population where care coordination is crucial.
Purpose of the Study:
- To investigate the association between multidisciplinary care (MDC) and survival.
- To determine the relationship between MDC and hospitalization risk in elderly outpatients with CKD.
Main Methods:
- Retrospective cohort study of 6978 elderly CKD patients (≥66 years) from 2001-2004.
- Propensity score matching (1:1) was used to compare patients in MDC clinics (n=187) versus non-MDC care.
- Cox proportional hazards models analyzed the association between MDC and mortality/hospitalization.
Main Results:
- Multidisciplinary care was associated with a 50% reduction in the risk for all-cause mortality (HR 0.50; 95% CI 0.35-0.71) after adjustments.
- No statistically significant difference was observed in all-cause hospitalization (HR 0.83; 95% CI 0.64-1.06) or cardiovascular-specific hospitalization (HR 0.76; 95% CI 0.54-1.06) for MDC patients.
- A trend towards reduced hospitalization risk was noted in the MDC group, though not statistically significant.
Conclusions:
- Multidisciplinary care is linked to a significant decrease in mortality risk for elderly CKD patients.
- Further research, including randomized controlled trials, is recommended to confirm these benefits and assess economic impact.
Abstract:
The effectiveness of multidisciplinary care (MDC) in improving health outcomes for patients with chronic kidney disease (CKD) is uncertain. This study sought to determine the association among MDC, survival, and risk for hospitalization among elderly outpatients with CKD. A total of 6978 patients who were 66 yr and older and had CKD were identified between July 1 and December 31, 2001, and followed to December 31, 2004; 187 (2.7%) were followed in an MDC clinic. Logistic regression was used to determine the propensity score (probability of MDC) for each patient, and MDC and non-MDC patients then were matched 1:1 on the basis of their score. A Cox model was used to determine the association between MDC and risk for death and hospitalization. After adjustment for age, gender, baseline GFR, diabetes, and comorbidity score, there was a 50% reduction in the risk for death for the MDC compared with the non-MDC group (hazard ratio [HR] 0.50; 95% confidence interval [CI] 0.35 to 0.71). There was no difference in the risk for all-cause (HR 0.83; 95% CI 0.64 to 1.06) or cardiovascular-specific hospitalization (HR 0.76; 95% CI 0.54 to 1.06) for the MDC compared with the non-MDC group. In conclusion, it was found that MDC was associated with a significant reduction in the risk for all-cause mortality and, although not statistically significant, a trend toward a reduction in risk for all-cause and cardiovascular-specific hospitalizations. The benefits of MDC and an assessment of their economic impact should be tested in a randomized, controlled trial.
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