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Related Experiment Video

Updated: Jul 17, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Fulminant postcesarean Clostridium difficile pseudomembranous colitis.

Sonia Ghai¹, Vikas Ghai, Shiraz Sunderji

¹The Toledo Hospital, Toledo, Ohio 43606, USA.

Obstetrics and Gynecology

|February 3, 2007

Summary

Pseudomembranous colitis, a rare complication of Clostridium difficile infection, can occur in postpartum women after antibiotic use. Prompt diagnosis and intervention are crucial for managing this serious condition.

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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

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Published on: December 8, 2014

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Last Updated: Jul 17, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

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Published on: December 10, 2016

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Gastroenterology

Background:

Pseudomembranous colitis, caused by Clostridium difficile infection, is infrequently documented in obstetric literature.
Antibiotic exposure is a known risk factor for developing this condition.

Observation:

A postpartum patient developed severe abdominal pain and distention following cesarean delivery and a course of intravenous and oral antibiotics.
Proctoscopy confirmed pseudomembranous colitis, necessitating colectomy with temporary ileostomy due to symptom severity and risk of perforation.

Findings:

The case highlights a rare instance of Clostridium difficile-associated pseudomembranous colitis in the postpartum period.
Aggressive antibiotic regimens, even in the early postpartum phase, may contribute to the development of this condition.

Implications:

Clinicians should consider pseudomembranous colitis in postpartum patients presenting with gastrointestinal distress and fever, especially after recent antibiotic use.
Early recognition and management are vital to prevent severe complications such as toxic megacolon or perforation.