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Four new nonaoxygenated C18 dibenzocylcooctadiene lignans from Kadsura philippinensis
Ya-Ching Shen1, Yu-Chi Lin, Atallah F Ahmed
1School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. ycshen@ntu.edu.tw
Abstract:
Four new nona-oxygenated C18 dibenzocyclooctadiene lignans, kadsuphilins C-F (1-4), were isolated from the EtOAc soluble portion of the alcoholic extract of the aerial parts of Kadsura philippinensis. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments, comparison of the spectral data with those of the related metabolites. The stereochemistries of the biphenyl and octadiene moieties were deduced from circular dichorism (CD) and the NOESY spectra, respectively. The in vitro antiplatelet aggregation activity of metabolites 1-4 also have been evaluated.
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