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Selective and effective cleavage of RNAs by vinyladenine-vinylamine copolymer
T Shiiba1, M Komiyama, E Yashima
1Institute of Material Science, University of Tsukuba, Ibaraki, Japan.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
Poly(uridylic acid) (poly[U]) and poly(adenylic acid) (poly[A]) are efficiently cleaved, via phosphodiester linkage hydrolysis, at pH 8, 50 degrees C by use of poly(vinyladenine-co-vinylamine) as catalyst. The catalytic activity of the copolymer surpasses the value of poly(vinylamine), indicating a significant role of the adenine residue in the copolymer for the effective catalysis.