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Enteric nervous system.

David Grundy1, Michael Schemann

  • 1Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK. d.grundy@sheffield.ac.uk

Current Opinion in Gastroenterology
|February 3, 2007
PubMed
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Recent research in enteric neurobiology reveals how the enteric nervous system is altered in disease and impacts energy balance. This advances understanding of gastrointestinal disorders.

Area of Science:

  • Gastrointestinal neurobiology
  • Neurogastroenterology
  • Gut-brain axis research

Background:

  • Enteric neurobiology investigates gastrointestinal (GI) function, integrating central mechanisms for food intake, illness behavior, and sensory processing.
  • The field is rapidly advancing, offering insights into complex physiological and pathological processes within the GI tract.

Purpose of the Study:

  • To highlight recent advancements in enteric neurobiology.
  • To focus on two key themes: alterations in the enteric nervous system in disease and its role in energy balance control.

Main Methods:

  • Review of recent scientific literature in enteric neurobiology.
  • Synthesis of findings related to disease pathophysiology and energy homeostasis.

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Main Results:

  • Recent studies reveal significant alterations in the enteric nervous system (ENS) associated with various diseases.
  • Emerging evidence underscores the critical role of enteric mechanisms in regulating energy balance and appetite.

Conclusions:

  • New basic science findings from the past year enhance understanding of GI pathophysiological processes.
  • This knowledge will facilitate improved diagnosis and treatment strategies for both organic and functional gastrointestinal disorders.