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Updated: Jul 17, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
A shape-persistent D,L-dipeptide building block for the assembly of rigidified oligopeptides
1Philipps-Universität Marburg, Fachbereich Chemie, Hans Meerwein Strasse, 35032, Marburg, Germany.
Abstract:
Mannuronic acid (5) was transformed into the densely functionalised D,L-dipeptide mimic 1 and subsequently inserted into the cyclic hexapeptide 3. The gulo-configurated seven-membered lactam 1 exhibits an inverted ring conformation compared to the previously described L,L-dipeptide mimic 2. In spite of this considerable difference, both prefer the same i to i + 1 positions of a beta-turn within a cyclic hexapeptide.
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