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Long-lasting changes of albino rats behavior and brain bioamines content after immunization against cholecystokinin-3
Igor Petrovich Ashmarin1, Raisa A Danilova, Maria F Obukhova
1Department of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow, Russia.
Abstract:
Active immunization against cholecystokinin fragments 31-33 (CCK-3) and 30-33 (CCK-4) results in long-lasting changes of albino rats' behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.
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