Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human bcr-abl gene has a lethal effect on embryogenesis.

N Heisterkamp1, G Jenster, D Kioussis

  • 1Section of Molecular Diagnosis, Childrens Hospital of Los Angeles, CA 90027.

Transgenic Research
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parasite Infections Influence Immunological Responses But Not Reproductive Success of Male Hellbender Salamanders (<i>Cryptobranchus alleganiensis</i>).

Integrative organismal biology (Oxford, England)·2025
Same author

Modulation of Paternal Care Behaviors in Response to Stream Conditions by Eastern Hellbenders (<i>Cryptobranchus alleganiensis alleganiensis</i>).

Integrative organismal biology (Oxford, England)·2025
Same author

Cancer-ID: Toward Identification of Cancer by Tumor-Derived Extracellular Vesicles in Blood.

Frontiers in oncology·2020
Same author

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression.

British journal of cancer·2015
Same author

Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Biochemical and Clinical Aspects.

Advances in experimental medicine and biology·2015
Same author

Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells.

Leukemia·2014

Introducing the bcr-abl oncogene into embryos did not result in live transgenic offspring. The bcr-abl gene product caused lethal developmental abnormalities during embryogenesis.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • The bcr-abl oncogene is implicated in chronic myelogenous leukemia (CML).
  • Understanding the oncogene's role in development is crucial.

Purpose of the Study:

  • To investigate the in vivo effects of the bcr-abl oncogene during embryonic development.
  • To determine if the bcr-abl gene product impacts embryogenesis.

Main Methods:

  • Transgenic mice were created by introducing the bcr-abl gene into fertilized one-cell embryos.
  • Embryos were re-implanted into foster mothers to assess development.
  • Observed outcomes included viability, gross abnormalities, and neoplastic formation.

Main Results:

Related Experiment Videos

  • No live transgenic progeny were obtained from the bcr-abl construct.
  • The bcr-abl gene product exhibited a pleiotropic lethal effect during embryogenesis.
  • Significant gross abnormalities were observed, but no neoplastic formations were detected.

Conclusions:

  • The bcr-abl oncogene product severely disrupts normal embryogenesis.
  • This suggests a critical role for bcr-abl in developmental processes beyond its known oncogenic function in CML.