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Updated: Jul 17, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Effect of polycyclic aromatic hydrocarbons on detection sensitivity of ultratrace nitroaromatic compounds
Abstract:
Polycyclic aromatic hydrocarbons (PAHs) with different numbers of pi-electrons and geometric symmetry of pi-systems, including anthracene, phenanthrene, pyrene, triphenylene, perylene, benzo[ghi]perylene, and coronene, were chosen to modify glassy carbon electrodes (GCEs) by self-assembling. The self-assembled monolayer of PAHs was investigated by STM and was used in the electrochemical detection of nitroaromatic compounds (NACs). The results indicate that PAH-modified GCE shows higher sensitivity to NACs than an unmodified one. Among the seven different PAHs, coronene-modified GCE exhibits the highest sensitivity to 2,4,6-trinitrotoluene and 1,3,5-trinitrobenzene.
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