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Related Experiment Videos

Cell culture process development: advances in process engineering.

Carole Heath1, Robert Kiss

  • 1Amgen, Seattle, Washington 98119, and Genentech, South San Francisco, California 94080, USA. kiss.robert@gene.com

Biotechnology Progress
|February 3, 2007
PubMed
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Cell culture process development experts shared advances in engineering, covering scales from 1 mL to 20,000 L. Discussions included high-throughput screening, bioreactor modeling, scale-up strategies, disposable technologies, and perfusion cultures.

Area of Science:

  • Biochemical Engineering
  • Biotechnology
  • Process Development

Background:

  • A session at the 2006 ACS National Meeting focused on cell culture process development.
  • Discussions spanned a wide range of scales, from micro-liter to large-scale bioreactors.

Framework:

  • Explored high-throughput cell culture screening systems.
  • Addressed bioreactor modeling and characterization, considering mixing and shear forces.
  • Examined systematic approaches for scale-up and scale-down.

Implementation:

  • Highlighted the development of disposable bioreactor technologies.
  • Showcased novel perfusion culture strategies.
  • Facilitated a valuable exchange of technical information.

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Implications:

  • Demonstrated significant interest and progress in the cell culture process development community.
  • Advanced understanding and application of process engineering in biotechnology.
  • Provided insights into optimizing cell culture processes for various applications.