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Metabonomics in pharmaceutical discovery and development.

Donald G Robertson¹, Michael D Reily, J David Baker

¹Metabonomics Evaluation Group, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. donald.robertson@pfizer.com

Journal of Proteome Research

|February 3, 2007

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Metabonomics, the study of small molecules, is crucial in pharmaceutical research for identifying drug targets and understanding diseases. This review covers analytical, statistical, and biological applications of metabonomics in drug discovery.

Area of Science:

Metabolomics and pharmaceutical sciences

Background:

Metabonomics is a key technology in drug discovery and development.
It serves as the small molecule complement to transcriptomics and proteomics.
It aids in target identification, phenotyping, and understanding disease biochemistry.

Purpose of the Study:

To review the applications of metabonomics in the pharmaceutical industry.
Focus on analytical, chemometric, and biological aspects.

Main Methods:

Review of current literature and industry practices in metabonomics.
Focus on analytical considerations.
Focus on chemometric and statistical methods.
Focus on biological applications.

Main Results:

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Metabonomics provides insights into disease mechanisms and toxicity.
Analytical and chemometric methods are critical for data interpretation.
Biological applications span target identification to drug efficacy assessment.

Conclusions:

Metabonomics is an integral part of modern pharmaceutical R&D.
Effective application requires robust analytical and statistical approaches.
Further integration of metabonomics will advance drug discovery.