Protein family classification with partial least squares
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Updated: Jul 17, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
Published on: June 6, 2025
Stephen O Opiyo1, Etsuko N Moriyama
1Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE 68583-0915, USA.
Abstract:
The quality of protein function predictions relies on appropriate training of protein classification methods. Performance of these methods can be affected when only a limited number of protein samples are available, which is often the case in divergent protein families. Whereas profile hidden Markov models and PSI-BLAST presented significant performance decrease in such cases, alignment-free partial least-squares classifiers performed consistently better even when used to identify short fragmented sequences.
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