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Formulation and evaluation of famotidine floating tablets
M Jaimini1, A C Rana, Y S Tanwar
1Bhupal Nobles' College of Pharmacy, Udaipur-313001, Rajasthan, India.
Current Drug Delivery
|February 3, 2007
Summary
This study developed famotidine gastroretentive floating tablets using effervescent techniques. The optimized formulation achieved sustained drug release and prolonged buoyancy for 6-10 hours.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Gastroretentive drug delivery systems enhance drug efficacy by prolonging gastric residence time.
- Famotidine is a histamine H2 receptor antagonist used to treat peptic ulcers and gastroesophageal reflux disease.
Purpose of the Study:
- To formulate and evaluate famotidine gastroretentive floating tablets using effervescent techniques.
- To investigate the influence of Methocel grades and citric acid on tablet properties and drug release.
Main Methods:
- Famotidine floating tablets were prepared using Methocel K100 and K15M with sodium bicarbonate and citric acid.
- Tablets were evaluated for physical characteristics, in vitro buoyancy, and dissolution.
- Gel-forming properties of Methocel grades were assessed.
Main Results:
- All prepared tablets demonstrated satisfactory physico-chemical properties and good in vitro buoyancy.
- Tablets remained buoyant for 6-10 hours, with Methocel K100 formulations showing longer buoyancy.
- Optimized buoyancy was achieved with 130mg sodium bicarbonate and 10mg citric acid.
- Sustained drug release was observed, consistent with non-Fickian transport.
Conclusions:
- The developed famotidine gastroretentive floating tablets are effective for sustained drug delivery.
- Methocel K100 is a suitable excipient for achieving prolonged buoyancy in effervescent floating systems.
- The formulation provides a promising approach for improving famotidine's therapeutic efficacy.
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