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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview01:13

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview

Attenuated total reflectance (ATR) infrared spectroscopy is a powerful analytical technique used to study the composition of materials. It is widely employed in chemistry, materials science, forensic science, and other fields where sample characterization is required. ATR has several advantages over traditional transmission IR spectroscopy, including the requirement of little to no sample preparation and the ability to analyze a wide range of samples.
The ATR process begins by directing a beam...
Qualitative Analysis01:10

Qualitative Analysis

Qualitative analysis is the process of identifying elements, ions, or compounds in an unknown sample. It is the first and most fundamental type of analysis based on the hierarchy of analytical goals. This hierarchy is significant as it provides a structured approach to scientific research, with qualitative analysis serving as the initial step, providing essential information before moving on to quantitative or other forms of analysis.
There are two main approaches to qualitative analysis:...

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Related Experiment Video

Updated: Jul 17, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Process analytical applications of Raman spectroscopy.

Jukka Rantanen1

  • 1Drug Discovery and Development Technology Center, Faculty of Pharmacy, PO Box 56, FIN-00014, University of Helsinki, Finland. jtr@dfuni.dk

The Journal of Pharmacy and Pharmacology
|February 3, 2007
PubMed
Summary

Raman spectroscopy offers real-time molecular insights into pharmaceutical manufacturing. This review explores its applications in solid dosage forms, highlighting process analytical technology benefits and challenges.

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Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds
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Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds

Published on: October 12, 2018

Related Experiment Videos

Last Updated: Jul 17, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds
09:11

Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds

Published on: October 12, 2018

Area of Science:

  • Pharmaceutical Manufacturing
  • Process Analytical Technology
  • Spectroscopy

Background:

  • Increasing demand for understanding chemical and physical phenomena in pharmaceutical unit operations.
  • Need for real-time process information for safer and efficient pharmaceutical manufacturing.
  • Raman spectroscopy offers molecular-level insights, positioning it as a future Process Analytical Tool (PAT).

Purpose of the Study:

  • To review applications of Raman spectroscopy in pharmaceutical solid dosage form process analysis.
  • To discuss challenges in interfacing Raman spectroscopy with process environments.
  • To address data management issues in pharmaceutical process analysis.

Main Methods:

  • Literature review of Raman spectroscopy applications in pharmaceutical solid dosage forms.
  • Analysis of interfacing challenges for in-line process monitoring.
  • Discussion of data management strategies for spectroscopic data.

Main Results:

  • Raman spectroscopy is a valuable tool for real-time monitoring of pharmaceutical solid dosage forms.
  • Interfacing and data management present significant challenges for widespread PAT implementation.
  • Successful application requires careful consideration of probe design and data handling protocols.

Conclusions:

  • Raman spectroscopy holds significant potential as a Process Analytical Technology (PAT) in pharmaceutical manufacturing.
  • Addressing technical challenges in process integration and data management is crucial for realizing its full benefits.
  • Further development is needed to optimize Raman spectroscopy for robust and reliable in-line pharmaceutical process analysis.