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Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
Published on: October 27, 2023
Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy
A M Checkley1, J Pepin, W C Gibson
1Hospital for Tropical Diseases, London, UK; University College Hospital, London, UK. annacheckley@yahoo.com
Abstract:
We describe a case of human African trypanosomiasis with a number of unusual features. The clinical presentation was subacute, but the infection was shown to be due to Trypanosoma brucei rhodesiense. The infection relapsed twice following treatment and the patient developed a melarsoprol-associated encephalopathy. Magnetic resonance imaging (MRI) findings were suggestive of microhaemorrhages, well described in autopsy studies of encephalopathy but never before shown on MRI. The patient survived severe encephalopathy with a locked-in syndrome. Our decision to provide ongoing life support may be useful to physicians treating similar cases in a setting where intensive care facilities are available.
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