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Related Experiment Video

Updated: Jul 17, 2026

Measuring Motor Coordination in Mice
10:07

Measuring Motor Coordination in Mice

Published on: May 29, 2013

Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout mice.

R Lalonde1, S Qian

  • 1Université de Rouen, Faculté de Médecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, IFRMP, 76183 Rouen Cedex, France. robert.lalonde@univ-rouen.fr

Behavioural Brain Research
|February 3, 2007
PubMed
Summary

Melanin concentrating hormone receptor-1 knockout mice exhibit increased activity and reduced anxiety. These behavioral changes in Mchr1 KO mice were observed across different genetic backgrounds without affecting learning or motor skills.

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Area of Science:

  • Neuroscience
  • Behavioral Genetics

Background:

  • The melanin concentrating hormone (MCH) system plays a role in regulating energy balance and mood.
  • Melanin concentrating hormone receptor-1 (Mchr1) is a key component of this system, mediating MCH signaling.

Purpose of the Study:

  • To investigate the behavioral phenotypes of Mchr1 knockout mice.
  • To assess the impact of Mchr1 deficiency on activity, anxiety, emotional reactivity, motor coordination, and spatial learning.

Main Methods:

  • Comparison of Mchr1 knockout (KO) male mice with wild-type littermates on 129/SvEv and C57BL/6J backgrounds.
  • Behavioral testing using photocell actimetry, elevated plus-maze, and assessment of fecal boli and vocalization.
  • Evaluation of motor coordination and spatial learning through established neurobehavioral paradigms.

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Last Updated: Jul 17, 2026

Measuring Motor Coordination in Mice
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Published on: May 29, 2013

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
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Main Results:

  • Mchr1 KO mice displayed significantly higher activity levels compared to wild-type controls.
  • Reduced anxiety-like behaviors were observed in Mchr1 KO mice on the C57BL/6J background (elevated plus-maze) and reduced emotional reactivity on the 129/SvEv background (fecal boli, vocalization).
  • No impairment in motor coordination or spatial learning was detected; Mchr1 KO mice showed improved performance in a water maze task on the 129/SvEv background.

Conclusions:

  • Mchr1 deficiency leads to increased locomotor activity and anxiolytic/reduced emotional reactivity phenotypes.
  • The absence of Mchr1 does not compromise motor coordination or spatial learning abilities.
  • Strain-dependent gene interactions influence body weight in Mchr1 KO mice.