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Elevated high sensitivity CRP levels in patients with mitral stenosis and left atrial thrombus

Ganesan Karthikeyan, Ajit Thachil, Sanjeev Sharma

    International Journal of Cardiology
    |February 3, 2007
    PubMed

    Insights

    Blood clots in the left atrium (LA) are common in mitral stenosis (MS). This study found elevated high-sensitivity C-reactive protein (hsCRP) levels, a marker of inflammation, are linked to LA thrombus formation in MS patients.

    Area of Science:

    • Cardiology
    • Hematology
    • Biochemistry

    Background:

    • Mitral stenosis (MS) causes blood stasis in the left atrium (LA), leading to thrombus formation.
    • The role of inflammation and procoagulant markers in LA thrombus development in MS requires further investigation.

    Purpose of the Study:

    • To investigate the contribution of abnormal homocysteine/folate/B12 levels, chronic inflammation, and procoagulant markers to LA thrombus formation in MS patients.

    Main Methods:

    • A case-control study design was employed.
    • Patients with MS were assessed for LA thrombus presence.
    • Levels of homocysteine, folate, B12, hsCRP, and other procoagulant markers were measured.

    Main Results:

    • Elevated high-sensitivity C-reactive protein (hsCRP) levels were significantly associated with the presence of LA thrombus.
    • This association remained independent of MS severity and its consequences.
    • No significant association was found for homocysteine, folate, or B12 levels.

    Conclusions:

    • Chronic inflammation, indicated by elevated hsCRP, is an independent risk factor for LA thrombus formation in patients with mitral stenosis.
    • These findings suggest that anti-inflammatory strategies may be beneficial in preventing LA thrombus in MS.

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