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Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?

Omer Dizdar1, Umut Kalyoncu, Omer Karadag

  • 1Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, 06100 Sihhiye, Ankara, Turkey. omerdiz@yahoo.com

Cytokine
|February 3, 2007
PubMed

Insights

Familial Mediterranean Fever (FMF) attacks show higher levels of macrophage inflammatory protein-1alpha (MIP-1alpha). This chemokine may play a role in FMF pathogenesis and link innate immunity to the disease.

Area of Science:

  • Immunology
  • Rheumatology
  • Genetics

Background:

  • Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder characterized by recurrent episodes of fever and inflammation.
  • The underlying mechanisms linking innate immunity to FMF pathogenesis require further elucidation.

Purpose of the Study:

  • To investigate the relationship between chemokines, specifically macrophage inflammatory protein-1alpha (MIP-1alpha), and inflammation in patients with FMF.
  • To assess the role of MIP-1alpha during acute FMF attacks versus remission.

Main Methods:

  • Serum MIP-1alpha levels were measured in 49 FMF patients (41 in remission, 8 in acute attack) and 20 healthy controls.
  • Disease activity parameters including fibrinogen, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were also assessed.

Main Results:

  • Serum MIP-1alpha levels were significantly elevated in FMF patients during acute attacks compared to both patients in remission and healthy controls (p=0.02 and p=0.038).
  • MIP-1alpha levels showed a weak positive correlation with CRP levels (r=0.32, p=0.032).

Conclusions:

  • Macrophage inflammatory protein-1alpha (MIP-1alpha) may be involved in the pathogenesis of FMF attacks.
  • Chemokines like MIP-1alpha could serve as a crucial link between the innate immune system and Familial Mediterranean Fever.

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