Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergence of Bacterial Leaf Blight of Rice in Madagascar: A Recent Introduction from Asia.

Phytopathology·2026
Same author

Tissue engineering approaches for the repair and regeneration of the anterior cruciate ligament: towards 3D bioprinted ACL-on-chip.

European cells & materials·2022
Same author

Trends in hepatitis C-related mortality in Switzerland.

Journal of viral hepatitis·2017
Same author

Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.

Alimentary pharmacology & therapeutics·2016
Same author

[Seoul hantavirus infection-associated hemorrhagic fever with renal syndrome in France: A case report].

La Revue de medecine interne·2016
Same author

Sorafenib with or without everolimus in patients with advanced hepatocellular carcinoma (HCC): a randomized multicenter, multinational phase II trial (SAKK 77/08 and SASL 29).

Annals of oncology : official journal of the European Society for Medical Oncology·2016

Related Experiment Video

Updated: Jul 17, 2026

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

Development of a multifunctional platform for extra- and intracellular ionic activities recording.

O T Guenat1, G Boulard, J-F Dufour

  • 1Inst. of Microtechnol., Neuchatel Univ., Switzerland.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary

Researchers developed versatile silicon nitride micropipettes for precise cellular tasks. These tools enable intracellular and extracellular recordings, and targeted drug delivery, advancing biological research.

More Related Videos

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique
09:18

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique

Published on: May 3, 2015

A Multi-Electrode Array Platform for Modeling Epilepsy Using Human Pluripotent Stem Cell-Derived Brain Assembloids
06:30

A Multi-Electrode Array Platform for Modeling Epilepsy Using Human Pluripotent Stem Cell-Derived Brain Assembloids

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Jul 17, 2026

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
11:08

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue

Published on: September 5, 2015

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique
09:18

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique

Published on: May 3, 2015

A Multi-Electrode Array Platform for Modeling Epilepsy Using Human Pluripotent Stem Cell-Derived Brain Assembloids
06:30

A Multi-Electrode Array Platform for Modeling Epilepsy Using Human Pluripotent Stem Cell-Derived Brain Assembloids

Published on: September 27, 2024

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Accurate manipulation and recording at the cellular level are crucial for understanding biological systems.
  • Existing micro tools often lack the versatility for multiple applications, such as simultaneous recording and drug delivery.
  • The development of novel materials and fabrication techniques is essential for creating advanced cellular interfaces.

Purpose of the Study:

  • To develop a multifunctional platform using silicon nitride micropipettes for advanced cellular operations.
  • To demonstrate the fabrication of high-precision micropipettes with tunable dimensions.
  • To showcase the utility of these micropipettes as ion-selective electrodes and drug microdispensers.

Main Methods:

  • Fabrication of silicon nitride micropipettes using a generic technology.
  • Characterization of micropipette dimensions, including outer diameter (300 nm to 6 µm) and wall thickness (150 nm to 500 nm).
  • Implementation of micropipettes for intracellular and extracellular recordings, and local drug microdispensing.

Main Results:

  • Successful fabrication of silicon nitride micropipettes with controlled nanoscale dimensions.
  • Demonstration of the platform's capability for both intracellular and extracellular ion-selective electrode recordings.
  • Validation of the micropipettes as effective local drug microdispensers.

Conclusions:

  • The developed silicon nitride micropipette platform offers a versatile solution for complex cellular operations.
  • The technology enables precise manipulation and recording, with potential applications in neuroscience and drug delivery research.
  • This advancement provides a foundation for next-generation tools in cellular biology and electrophysiology.