Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vivo transfection microsystems.

F Rivera1, J Berthier, M Cochet

  • 1Microsyst. for Biol. & Health Dept., CEA-LETI, Grenoble, France.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic-assisted partial nephrectomy (RAPN) and standardization of outcome reporting: a prospective, observational study on reaching the "Trifecta and Pentafecta".

Journal of robotic surgery·2020
Same author

A multivariate Th17 metagene for prognostic stratification in T cell non-inflamed triple negative breast cancer.

Oncoimmunology·2019
Same author

Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol.

Regulatory toxicology and pharmacology : RTP·2019
Same author

Publisher Correction: Model-Based Therapy Planning Allows Prediction of Haemodynamic Outcome after Aortic Valve Replacement.

Scientific reports·2019
Same author

Changes in Clostridium (Clostridioides) difficile PCR-Ribotype Distribution and Antimicrobial Resistance in a German Tertiary Care Hospital Over the Last 10 Years.

Current microbiology·2019
Same author

Catheter ablation in ASymptomatic PEDiatric patients with ventricular preexcitation: results from the multicenter "CASPED" study.

Clinical research in cardiology : official journal of the German Cardiac Society·2018

This study introduces a novel, minimally invasive microfluidic device for in vivo electrotransfer. This innovative tool enhances drug and gene delivery efficiency in deep tissues with reduced side effects.

Area of Science:

  • Biomedical Engineering
  • Cellular Biology
  • Drug Delivery Systems

Background:

  • In vivo transfection methods like viral and chemical approaches face limitations in efficiency and side effects.
  • Electrical transfection offers higher efficiency for molecular delivery into cells.
  • Existing in vivo electrotransfer devices are often invasive, limiting their application in deep tissues.

Purpose of the Study:

  • To develop a novel, minimally invasive microfluidic device for in vivo electrotransfer.
  • To enable efficient delivery of therapeutic molecules, genes, or drugs into targeted deep tissues.
  • To provide a versatile platform for electrotransfection, drug delivery, and electrostimulation.

Main Methods:

  • Development of a compact, standalone microfluidic microdevice with a 500 µm square section.

Related Experiment Videos

  • Integration of high-voltage electrical impulse application capabilities.
  • Design focused on minimal invasiveness for insertion into deep tissue regions.

    • Main Results:

    • The microdevice is small enough for insertion into deep tissue regions with minimal drawbacks.
    • The device facilitates the injection of therapeutic molecules, genes, or drugs into targeted tissues.
    • The platform supports high-voltage electric impulse application for efficient electrotransfer.

    Conclusions:

    • The presented microfluidic device offers a promising solution for minimally invasive in vivo electrotransfer.
    • This generic tool expands the possibilities for targeted drug delivery, gene therapy, and electrostimulation.
    • The device's design overcomes the invasiveness limitations of previous in vivo electrotransfer systems.