Jove
Visualize
Contact Us

Related Experiment Videos

Implantable microchips for controlled drug delivery.

J M Maloney1, J T Santini

  • 1MicroCHIPS, Inc., Bedford, MA, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary

A new implantable drug delivery system offers controlled release of multiple therapeutic doses, reducing the need for frequent injections. This technology ensures reliable and repeatable drug delivery for various therapeutic compounds.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microchip technology in drug delivery.

Annals of medicine·2000
Same author

Microchips as Controlled Drug-Delivery Devices.

Angewandte Chemie (International ed. in English)·2000
Same author

Tazarotene gel is safe and effective in the treatment of acne vulgaris: a multicenter, double-blind, vehicle-controlled study.

Cutis·1999
Same author

A controlled-release microchip.

Nature·1999
Same author

Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis.

International journal of dermatology·1998
Same author

Current therapy for cutaneous melanoma.

Journal of the American Academy of Dermatology·1996
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Pharmacology

Background:

  • Frequent injections are often required for potent therapeutic compounds, impacting patient compliance and treatment efficacy.
  • Existing drug delivery systems may lack the capability for precise, multi-dose administration or stable long-term storage of diverse drug formulations.
  • The need for advanced drug delivery solutions that enable complex dosing regimens and improve therapeutic outcomes is critical.

Purpose of the Study:

  • To report the development of an implantable drug delivery system for controlled, multi-dose administration.
  • To demonstrate the system's capability for stable, hermetic storage of therapeutic drugs in various forms (solid, liquid, gel).
  • To evaluate the reliability and repeatability of the microchip drug release technology through in vitro and in vivo studies.

Related Experiment Videos

Main Methods:

  • Development of an implantable microchip-based drug delivery device.
  • Incorporation of individual compartments for discrete dose storage.
  • In vitro and in vivo release studies to assess drug delivery performance.
  • Evaluation of hermetic sealing for drug stability.

Main Results:

  • Successful demonstration of controlled drug release from the implantable system.
  • Confirmation of stable and hermetic storage for therapeutic compounds.
  • Reliable and repeatable drug release profiles observed in both in vitro and in vivo experiments.
  • Feasibility of multiple-drug regimens (pulsatile or continuous) established.

Conclusions:

  • The developed implantable drug delivery system effectively controls the release of multiple individual doses.
  • The technology provides a reliable and repeatable method for administering potent therapeutics, potentially reducing injection frequency.
  • This system offers a promising platform for advanced, personalized drug therapy regimens.