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Computing work in the ischemic heart.

S A Niederer1, M L Buist, A J Pullan

  • 1Insitiute of Bioengineering and Department of Engineering Science. The University of Auckland, Auckland, New Zealand.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
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This study models how poorly perfused cardiac tissue affects heart function. Ischemic regions significantly reduce active tension, impacting overall ventricular pump performance.

Area of Science:

  • Cardiovascular Physiology
  • Computational Biology
  • Biomedical Engineering

Background:

  • Cardiac tissue perfusion is critical for normal heart function.
  • Ischemia, or poor perfusion, alters cellular electrophysiology and mechanics.
  • Understanding these changes is vital for diagnosing and treating heart conditions.

Purpose of the Study:

  • To analyze the impact of an ischemic region on active tension and strain within a cardiac ventricle model.
  • To quantify the reduction in cellular active tension and workload caused by ischemia.
  • To assess the overall effect of ischemic regions on left and right ventricular pump function.

Main Methods:

  • Developed a coupled electromechanical cell model to simulate cellular active mechanics and electrophysiology.

Related Experiment Videos

  • Adapted the Noble 98-HMT cell model to create an ischemic cell model with altered electrophysiological properties.
  • Integrated the ischemic cell model into a cardiac ventricle model with an anisotropic constitutive law to calculate deformation and active tension.
  • Solved the model with and without the ischemic region to compare stress and strain distributions.

    • Main Results:

    • The ischemic cell model exhibited a raised resting potential, shortened action potential duration, and reduced amplitude.
    • Ischemic cells generated negligible active tension, reducing their workload by several orders of magnitude.
    • The presence of an ischemic region significantly affected the pump function of both the left and right ventricles.

    Conclusions:

    • Ischemia drastically reduces the active tension generated by cardiac cells.
    • Even localized ischemic regions can have a substantial negative impact on global cardiac pump efficiency.
    • Computational modeling provides valuable insights into the mechanical consequences of myocardial ischemia.