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Related Experiment Videos

A structural constitutive model for the native pulmonary valve.

Michael S Sacks1, Thanh V Lam, John E Mayer

  • 1Department of Bioengineering, University of Pittsburgh, PA, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary

Understanding pulmonary valve (PV) function is crucial for tissue engineered valve replacement. This study quantifies porcine PV biaxial mechanics and develops the first structural constitutive model for PV function.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Tissue Engineering

Background:

  • Pulmonary valve (PV) replacement with tissue engineered valves necessitates a deep understanding of native PV function.
  • Current knowledge gaps exist regarding the specific mechanical properties of the PV.

Purpose of the Study:

  • To quantify the biaxial mechanical behavior of the porcine pulmonary valve.
  • To develop a structural constitutive model for the porcine PV based on its mechanical properties.

Main Methods:

  • Biaxial mechanical testing was performed on porcine PV tissue samples.
  • Data from mechanical tests were used to formulate a structural constitutive model.

Main Results:

  • The study successfully quantified the biaxial mechanical behavior of the porcine PV.

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  • A novel structural constitutive model for the porcine PV was developed.

    • Conclusions:

    • This research provides the first structural constitutive model for the porcine PV.
    • The findings are essential for advancing the design and development of tissue engineered PV replacements.