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Related Experiment Video

Updated: Jul 17, 2026

Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination

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Published on: July 29, 2015

Vision rehabilitation with the optic nerve visual prosthesis.

C Veraart¹, F Duret, M Brelen

¹Neural Rehabilitation Engineering Laboratory, Universite Catholique de Louvain, Brussels, Belgium.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

|February 3, 2007

Summary

A novel optic nerve visual prosthesis successfully activated retinal ganglion cell axons in a blind volunteer. This technology can evoke visual phosphenes and aid in object localization and discrimination.

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Area of Science:

Ophthalmology
Neuroscience
Biomedical Engineering

Background:

Retinitis pigmentosa causes progressive vision loss.
Visual prostheses aim to restore sight by bypassing damaged retinal cells.
Optic nerve stimulation offers a potential pathway for visual information delivery.

Purpose of the Study:

To evaluate the safety and efficacy of a chronically implanted optic nerve visual prosthesis.
To assess the ability of electrical stimulation to evoke visual percepts (phosphenes).
To determine if the prosthesis can provide useful visual information for object perception.

Main Methods:

Chronic implantation of an optic nerve visual prosthesis in a volunteer with retinitis pigmentosa.
Controlled electrical stimulation of the optic nerve.
Subjective reporting of elicited sensations (phosphenes) and visual experiences.

Main Results:

Successful activation of retinal ganglion cell axons.
Evocation of distinct phosphenes across a wide visual field.
No non-visual sensations were reported.
Demonstrated ability to convey visual information for object localization and discrimination.

Conclusions:

Chronic optic nerve stimulation is feasible for visual prosthesis application.
The visual prosthesis effectively transmitted visual information.
This technology shows promise for restoring functional vision in individuals with retinitis pigmentosa.